The Anti-MCV ELISA by ORGENTEC detects autoantibodies against mutated citrullinated vimentin, MCV, and is an efficient and reliable serological test for rheumatoid arthritis. Anti-MCV detects the disease at a very early stage, even in patients who test negative for rheuma- toid factor, and to some degree even before the appearance of specific clinical symptoms.
Autoantibodies against mutated citrullinated vimentin are highly specific and extremely sensitive markers for rheumatoid arthritis (specificity 97 %, sensitivity > 82 %). MCV auto- antibodies are an indicator of advanced injury to the joints and aggressive progression of the disease. In contrast to the detection of anti- bodies against synthetic cyclic citrullinated peptides, changes in the anti-MCV concentration correspond to changes of clinical parameters. As well as allowing for an unambiguous diagnosis, the Anti-MCV ELISA thus also makes it possible to monitor therapeutic progress.
For point-of-care diagnosis, rheumachec® pro- vides a rapid blood test that detects both anti-MCV and rheumatoid factor.
LinkOut to rheumachec® homepage
ORGENTEC-Service: recommended reading
Anti-MCV® and ACPA |
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| Tests |
12 x 8 determinations
12 or 24 Alegria® test strips |
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| Calculation |
quantitative |
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| Range |
0-1000 U/ml |
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| Cut-off |
20 U/ml |
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| Sensitivity |
1 U/ml |
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| Calibration |
arbitrary |
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| Substrate |
TMB (450 nm) |
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| Antigens |
MCV (mutated
citrullinated vimentin) |
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Instruction for Use: ORG 548-0802-03-gb.pdf
Material-Safety-Datasheet: ORG 548-msds-v2.pdf
Poster EULAR 2007: MCV_Poster_Eular.pdf