The Anti-TG ELISA by ORGENTEC detects autoantibodies against thyroglobulin in human serum.
Thyroglobulin is a water-soluble glycoprotein with a molecular weight of about 660,000 Daltons. It is produced in the thyroid gland and, at 75 %, is the main protein component of the thyroid. Thyroglobulin is responsible for the production and storage of thyroid hormones. For the synthesis of thyroid hormones T3 and T4, two tyrosine moieties of the thyroglobulin molecule are iodised, linked together, and proteolytically cleaved from the protein.
Thyroglobulin is a strong autoantigen. B-lympho- cytes with membrane-contained IgM antibodies against thyroglobulin are even detected in the blood of healthy people. Together with anti- bodies against thyroperoxidase (Anti-TPO), high titres of IgG antibodies against thyroglobulin are markers for Hashimoto-type chronic autoim- mune thyroiditis. Thyroglobulin antibodies are found in 50 to 60 % of patients with Hashimoto’s thyroiditis. |
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| Tests |
12 x 8 determinations
12 or 24 Alegria® test strips |
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| Calculation |
quantitative |
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| Range |
0-9000 IU/ml |
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| Cut-off |
150 IU/ml |
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| Sensitivity |
10 IU/ml |
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| Calibration |
WHO 65 / 93 |
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| Substrate |
TMB (450 nm) |
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| Antigens |
Thyroglobulin (human) |
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Instruction for Use: ORG 502-0802-04-gb.pdf
Material-Safety-Datasheet: ORG 502-msds-v3.pdf