Beta-2 microglobulin, the light chain of the class I major histocompatibility complex (HLA I, MHC I) is a tumour marker in cases of multiple myeloma, Hodgkin’s disease, chronic lympho- cytic leukaemia, and other non-Hodgkin’s lym- phomas. Other diseases (infections, autoim- mune diseases) that involve activation of the cellular immune system also give rise to increased beta-2 microglobulin concentrations in serum.
Beta-2 microglobulin is also used as a marker for the evaluation of the glomerular filtration rate, for the diagnosis and monitoring of tubulo- interstitial kidney damage, for the evaluation of kidney function after a kidney transplant, and in the monitoring of HIV infections.
The beta-2-Microglobulin assay by ORGENTEC is an ELISA for the quantitative detection of beta-2 microglobulin in urine, serum, or plasma. The wells of the microplate are coated with highly specific antibodies against human beta-2 microglobulin. |
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| Tests |
12 × 8 determinations |
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| Calculation |
quantitative |
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| Range |
0-12 μg/ml |
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| Normal value |
urine: 0-0.3 μg/ml
serum/plasma: 0-3 μg/ml |
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| Sensitivity |
0.1 μg/ml |
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| Substrate |
TMB (450 nm) |
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| Coating |
anti-beta-2-microglobulin
antibodies (polyclonal, rabbit) |
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Instruction for Use: ORG 5BM-0802-02-gb.pdf
Material-Safety-Datasheet: ORG 5BM-msds-v3.pdf