Anti-Cathepsin G

Anti-Cathepsin G is an ELISA-based in-vitro test system for the quantitative determination of IgG antibodies against cathepsin G in human serum or plasma. It is used for the differentiation of a positive pANCA immunofluorescence pattern. Cathepsin G antibodies are found in cases of systemic vasculitis, inflammatory rheumatic diseases (SLE, Sjögren’s syndrome, Felty’s syndrome), autoimmune hepatitis, and chronic inflammatory bowel diseases.

Cathepsins are intracellular proteases of the lysosome. Their hydrolytic activity significantly contributes to the destruction of bone matrix. Autoantibodies against cathepsin G give a perinuclear (pANCA) or atypical (xANCA) fluorescence pattern in indirect fluorescence on ethanol-fixed granulocytes. Patient sera that display such an immunofluorescence pattern but give a negative Anti-MPO ELISA result should be tested for cathepsin G antibodies, among others.

Specifications

Product Number ORG 525
Tests12 x 8 tests
Calibrationinternal
Calculationquantitative
Range0 - 100 U/ml
Cut-off10 U/ml
Coating cathepsin G
Alegria

ORG 225  

ELISA

ORG 530  

Documentation

Instruction for Use
Safety Data Sheet