Anti-DGP

Anti-DGP IgA is an ELISA test for the quantitative determination of IgA and/or IgG antibodies against deamidated gliadin peptide epitopes (DGP) in human serum or plasma. The assays Anti-DGP IgA, Anti-DGP IgG, and Anti-DGP Screen are used to support a diagnosis of celiac disease. After resorption, gliadin from food is deamidated by tissue transglutaminase (tTG) in the gastric mucosa. Gliadin fragments (deamidated gliadin peptides) bind to the HLA molecules of antigen-presenting cells. Once placed in context with specific HLA molecules, the fragments are recognized by corresponding T-helper cells. This results in an extensive immune response that includes formation of antibodies against tTG and DGP. In serum samples from celiac patients, IgA and IgG antibodies against deamidated gliadin peptide epitopes are found. The IgA antibodies make it possible to determine the level of disease activity and to monitor adherence to a gluten-free diet. Because a substantial percentage of celiac patients are deficient in IgA antibodies, sensitive screening of individuals at risk always also includes testing for IgG antibodies. Anti-DGP Screen detects antibodies of both subclasses, IgA and IgG in a single test step, and thus also identifies celiac disease patients with IgA deficiency.

Anti-DGP IgA

Anti-DGP IgA is an ELISA test for the quantitative determination of IgA and/or IgG antibodies against deamidated gliadin peptide epitopes (DGP) in human serum or plasma. The assays Anti-DGP IgA, Anti-DGP IgG, and Anti-DGP Screen are used to support a diagnosis of celiac disease.

Specifications

Product Number ORG 551A
Tests12 x 8 tests
Calibrationinternal
Calculationquantitative
Range0 - 100 U/ml
Cut-off10 U/ml
Coating deamidated gliadin proteins (DGP)
Alegria

ORG 251A   ORG 251G   ORG 251S  

Documentation

Instruction for Use
Safety Data Sheet

Anti-DGP IgG

Anti-DGP IgG is an ELISA test for the quantitative determination of IgG antibodies against deamidated gliadin protein epitopes (DGP) in human serum or plasma. These assays are used to support a diagnosis of celiac disease.

Specifications

Product Number ORG 551G
Tests12 x 8 tests
Calibrationinternal
Calculationquantitative
Range0 - 100 U/ml
Cut-off10 U/ml
Coating deamidated gliadin proteins (DGP)
Alegria

ORG 251A   ORG 251G   ORG 251S  

Documentation

Instruction for Use
Safety Data Sheet

Anti-DGP Screen

Anti-DGP Screen is an ELISA test for the quantitative determination of IgA and IgG antibodies against deamidated gliadin protein epitopes (DGP) in human serum or plasma. These assays are used to support a diagnosis of celiac disease. After resorption, gliadin is deamidated by tissue transglutaminase (tTG) in the gastric mucosa. Gliadin fragments (deamidated gliadin peptides) bind to the HLA molecules of antigen-presenting cells. Once placed in context with specific HLA molecules, the fragments are recognized by corresponding T-helper cells. This results in a comprehensive immune response that includes formation of antibodies against tTG and DGP. In serum samples from celiac patients, IgA and IgG antibodies against deamidated gliadin peptide epitopes are found. The IgA antibodies make it possible to determine the level of disease activity and to monitor adherence to a gluten-free diet. Because a substantial percentage of celiac patients are deficient in IgA antibodies, sensitive screening of individuals at risk always also includes testing for IgG antibodies. The Anti-DGP screen, which detects both IgA and IgG in a single test, also identifies these IgA deficient patients, eliminating the need for a separate IgA test.

Specifications

Product Number ORG 551S
Tests12 x 8 tests
Calibrationinternal
Calculationquantitative
Range0 - 100 U/ml
Cut-off10 U/ml
Coating deamidated gliadin proteins (DGP)
Alegria

ORG 251A   ORG 251G   ORG 251S  

Documentation

Instruction for Use
Safety Data Sheet