Anti-Scl-70

Anti-Scl-70 is an ELISA test for the quantitative determination of IgG antibodies against Scl-70 (DNA topoisomerase I) in human serum or plasma.

With a specificity near 100 %, these antibodies are an accepted and highly specific marker for progressive systemic scleroderma; autoantibodies against topoisomerase I are extremely rare in both healthy individuals and those with non-autoimmune diseases. In addition to the serological diagnosis of systemic scleroderma, ORGENTEC’s Anti-Sci-70 test is also useful in the differential diagnosis of Raynaud’s phenomenon. Autoantibodies against topoisomerase I are also a prognostic marker for the further development of systemic sclerosis.

Specifications

Product Number ORG 512
Tests12 x 8 tests
CalibrationCDC sera
Calculationquantitative
Range0 - 200 U/ml
Cut-off25 U/ml
Coating Scl-70 protein (DNA topoisomerase I)
Alegria

ORG 200   ORG 206   ORG 212   ORG 238  

ELISA

ORG 506   ORG 514   ORG 538   ORG 539   ORG 546   ORG 600  

BLOT

ORG 710   ORG 711  

Documentation

Instruction for Use
Safety Data Sheet