ThromboCombo IgG/IgM

ThromboCombo IgG/IgM is an ELISA test for the quantitative determination of IgG and IgM antibodies against four anionic phospholipids (cardiolipin, phosphatidyl serine, phosphatidyl inositol, phosphatidic acid) as well as beta-2-glycoprotein I in human serum or plasma.
The detection of cardiolipin antibodies is one of the criteria for the diagnosis of antiphospholipid syndrome (APS). In rare cases, these autoantibodies are absent, despite symptoms of APS, and several other phospholipid antibodies are mostly found instead. Cardiolipin antibodies are also an accepted classification criterion for systemic lupus erythematosus (SLE).
The wells of the ThromboCombo ELISA are individually coated with the five antigens as well as a mixture of all four phospholipids with and without the beta-2-glycoprotein I cofactor. Each individual microplate can thus be used to establish twelve differentiated patient profiles.

Specifications

Product Number ORG 555
Tests12 x 8 tests
CalibrationHarris sera, IRP 97/656 (IgG), HCAL (IgG) / EY2C9 (IgM)
Calculationquantitative
RangeIgG: 0 - 100 GPL-U/ml; IgM: 0 - 100 MPL-U/ml
Cut-offIgG: 10 GPL-U/ml; IgM: 10 MPL-U/ml
Coating beta-2-glycoprotein I (beta-2-GPI), phosphatidic acid, phosphatidyl inositol, phosphatidyl serine, cardiolipin

Documentation

Instruction for Use
Safety Data Sheet