ENAscreen

ENAscreen is an ELISA-based screening test for the qualitative determination of IgG antibodies against components of the cell nucleus in human serum or plasma.

Besides DNA and histones, autoantibodies may also target other nuclear antigens. These nuclear antigens were named extractable nuclear antigens (ENA), as originally they were extracted from the nuclei with saline solution. Autoantibodies to Smith antigen (Sm) which is also considered to be highly specific for SLE were the first anti-ENA detected. Thereafter, further subtypes of ENA i.e. ribonucleoproteins (RNP), the Sjoegren antigens SS-A and SS-B, Scl-70, and Jo-1 were identified. Each individual well of the ENAscreen test is coated with a mixture of six highly purified antigens. For further differentiation, a positive result with this ELISA may then be followed up with ENAcombi or the ORGENTEC test kits for quantitative determination of the individual ENA specificities.

Specifications

Product Number ORG 206
Tests24 Alegria® strips
CalibrationCDC sera
Calculationqualitative
Cut-offIndex > 1.0
Coating histidyl-tRNA synthetase (Jo-1), RNP/Sm complex, Scl-70 protein (DNA topoisomerase I), Sm ribonucleoproteins, SS-A 52 (Ro 52), SS-A 60 (Ro 60), SS-B (La)
Alegria

ORG 200   ORG 213   ORG 238   ORG 211   ORG 212   ORG 210   ORG 208   ORG 252   ORG 260   ORG 209  

ELISA

ORG 506   ORG 513   ORG 514   ORG 538   ORG 539   ORG 546   ORG 600   ORG 511   ORG 544   ORG 512   ORG 510   ORG 508   ORG 652   ORG 660   ORG 509  

BLOT

ORG 710   ORG 711   ORG 760  

Documentation

Instruction for Use
Safety Data Sheet