Anti-Nucleosome is an ELISA-based, automated, in-vitro test system for the quantitative determination of IgG antibodies against parts of the nucleosome, a structural component of chromatin, in human serum or plasma.

This sensitive and specific serological test assists in the diagnosis of systemic lupus erythematosus (SLE) and drug-induced lupus (DIL). It is more sensitive than the test for dsDNA antibodies, and the anti-nucleosome antibodies can be detected earlier than anti-dsDNA antibodies. They thus provide a valuable indicator for the early diagnosis of emerging SLE in cases where SLE is suspected but dsDNA antibodies are not detected.


Product Number ORG 228
Tests24 Alegria® strips
Range0 - 200 U/ml
Cut-off 20 U/ml
Coating nucleosomes (human)

ORG 528  


ORG 711  


Instruction for Use
Safety Data Sheet

Document Archive
Instruction for Use Revision 4. Earlier versions and additional languages can be found in the document archive.