Anti-EBV (VCA) IgG Liquor

The Alegria® Anti-EBV (VCA) IgG Liquor is an ELISA based test system intended for the comparative quantitative measurement of IgG class antibodies against EBV (VCA) in human serum or plasma samples and in cerebrospinal fluid (CSF). This assay is used for the detection of IgG antibody synthesis in the central nervous system.

The detection of pathogen-specific antibody production in CSF plays a role in the diagnosis of acute neurological infections. The antibody index (AI) reflects the ratio of EBV-specific antibodies between CSF and serum. Calculation of the AI is based on testing for pathogen-specific antibodies in a CSF sample and a corresponding serum sample from the patient to detect specific intrathecal antibody production.
The Epstein-Barr virus (EBV) is a member of the herpes virus family. After primary infection with a lytic multiplication cycle, herpes viruses typically remain latent in the body for the patient’s lifetime.
In childhood, infections with EBV usually pass subclinically or with very mild clinical symptoms. Primary infection in adolescents and adults can lead to symptoms of infectious mononucleosis. Complications of an Epstein-Barr infection can result in a variety of neurological inflammatory processes (e.g. EBV encephalitis, meningitis, peripheral facial nerve paresis, acute myelopathies, radiculitis), though only in very rare cases. The detection of intrathecal IgG production against EBV is very useful for confirming a diagnosis, as well as for the differential diagnosis of neurological inflammatory processes of different etiology.

Specifications

Product Number ORG 901GL
Tests24 Alegria® strips
Calibrationinternal
Calculationquantitative
Range10 - 200 U/ml
Cut-off10 U/ml
Coating EBV viral capsid peptide (VCAp18) (recombinant) , EBV viral capsid peptide (VCAp23) (recombinant)
Alegria

ORG 901G   ORG 901MX  

Documentation

Instruction for Use
Safety Data Sheet
Product Information