Anti-Rubella Virus IgG Liquor

Anti-Rubella Virus IgG Liquor is an ELISA based test system intended for the comparative quantitative measurement of IgG class antibodies against Rubella Virus in human serum or plasma samples and in cerebrospinal fluid (CSF). This assay is applicable for the detection of IgG antibody synthesis in the central nervous system.

Rubella infection sometimes leads to serious neurological complications, including Guillain-Barre Syndrome (GBS), and encephalitis. Rubella virus causes severe brain injury in children if their mother is infected in early pregnancy. The brain injury is caused by meningoencephalitis, a part of the “congenital rubella syndrome”. Rubella virus can also cause a progressive “pan-encephalitis” later in life in children who were infected in the womb and survived but remain chronically infected.
In chronic diseases with CNS involvement, e.g. multiple sclerosis (MS) or Lupus with neurological manifestations, an elevated antibody index of anti-measles virus, anti-rubella virus and / or anti-varicella zoster virus can be detected in the CSF. This MRZ reaction is the most sensitive biochemical method for the detection of the pathological immune process in the CNS when the first clinical symptoms of MS appear. In about 90% of MS patients, an increased antibody index against the MRZ combination can be detected.

Specifications

Product Number ORG 919GL
Tests24 Alegria® Test Strips
Calibrationinternal
Calculationquantitative
Range10-200 U/ml
Coating purified inactivated Rubella-Virus particles (strain HPV-77)

Documentation

Instruction for Use
Safety Data Sheet
Product Information