Anti-Helicobacter pylori

Helicobacter pylori is a Gram-negative, helical bacterium that colonizes the human stomach. More virulent type I strains are differentiated from less virulent type II strains. The former have additional pathogenic factors like vacuolating cytotoxin VacA and cytotoxin-associated CagA. About half of the global human population is infected with H. pylori. The infection is often acquired in early childhood and usually remains undetected. However, about 10-20 % of infected individuals develop severe stomach problems ranging from gastric ulcers to lymphoma and adenocarcinoma of the stomach. Left untreated, H. pylori generally remains in the stomach throughout the life of the individual. Eradication is only possible by treatment with a combination of special antibiotics. There are a variety of invasive and non-invasive methods for detecting H. pylori infections. Non-invasive serological analyses are easy to carry out and have high sensitivity and specificity. Antibodies against the bacterial pathogenicity factors, particularly CagA are statistically more prevalent in cases of more serious infection. Specific antibodies against H. pylori are detectable by ELISA shortly after infection. The immune response to H. pylori generally begins with the formation of IgM antibodies, followed by increasing titres of IgG and IgA antibodies, which remain over the course of the infection.

Anti-Helicobacter pylori IgA

Alegria® Anti-Helicobacter pylori IgA is an ELISA-based, automated, in-vitro test system for the quantitative determination of IgA antibodies against Helicobacter pylori in human serum or plasma.

Specifications

Product Number ORG 917A
Tests24 Alegria® strips
Calibrationinternal
Calculationquantitative
Range0 - 200 U/ml
Cut-off25 U/ml
Coating CagA (recombinant), Helicobacter pylori whole-cell lysate

Documentation

Instruction for Use
Safety Data Sheet
Product Information

Anti-Helicobacter pylori IgG

Alegria® Anti-Helicobacter pylori IgG is an ELISA-based, automated, in-vitro test system for the quantitative determination of IgG antibodies against Helicobacter pylori in human serum or plasma.

Specifications

Product Number ORG 917G
Tests24 Alegria® strips
Calibrationinternal
Calculationquantitative
Range0 - 200 U/ml
Cut-off25 U/ml
Coating CagA (recombinant), Helicobacter pylori whole-cell lysate

Documentation

Instruction for Use
Safety Data Sheet
Product Information