Anti-Scl-70 is an ELISA test for the quantitative determination of IgG antibodies against Scl-70 (DNA topoisomerase I) in human serum or plasma.

With a specificity near 100 %, these antibodies are an accepted and highly specific marker for progressive systemic scleroderma; autoantibodies against topoisomerase I are extremely rare in both healthy individuals and those with non-autoimmune diseases. In addition to the serological diagnosis of systemic scleroderma, ORGENTEC’s Anti-Sci-70 test is also useful in the differential diagnosis of Raynaud’s phenomenon. Autoantibodies against topoisomerase I are also a prognostic marker for the further development of systemic sclerosis.


Product Number ORG 512
Tests12 x 8 tests
CalibrationCDC sera
Range0 - 200 U/ml
Cut-off25 U/ml
Coating Scl-70 protein (DNA topoisomerase I)

ORG 200   ORG 206   ORG 212   ORG 238  


ORG 506   ORG 514   ORG 538   ORG 539   ORG 546   ORG 600  


ORG 710   ORG 711  


Instruction for Use
Safety Data Sheet

Document Archive
Instruction for Use Revision 3. Earlier versions and additional languages can be found in the document archive.
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