Anti-Elastase

Anti-Elastase is an ELISA-based, automated, in-vitro test system for the quantitative determination of IgG antibodies against elastase in human serum or plasma.
These autoantibodies are particularly common in patients with chronic inflammatory bowel diseases and autoimmune hepatitis.

Elastase is a serine protease. Its proteolytic effect plays a role in the destruction of tissue that is associated with rheumatoid arthritis and pulmonary emphysema. Like autoantibodies against myeloperoxidase (MPO), elastase autoantibodies are antineutrophil cytoplasmic antibodies, which evince a perinuclear fluorescence pattern (pANCA) in indirect immunofluorescence. Serum samples that display such a pANCA pattern but give a negative Anti-MPO ELISA result should be tested for autoantibodies against elastase, as well as antibodies against cathepsin G, lysozyme, and lactoferrin.

Specifications

Product Number ORG 224
Tests24 Alegria® strips
Calibrationinternal
Calculationquantitative
Range0 - 100 U/ml
Cut-off 10 U/ml
Coating elastase
ELISA

ORG 524   ORG 530  

Documentation

Instruction for Use
Safety Data Sheet

Document Archive
Instruction for Use Revision 4. Earlier versions and additional languages can be found in the document archive.

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