Anti-PR3

Anti-PR3 is an ELISA-based, automated, in-vitro test system for the quantitative determination of IgG antibodies against proteinase 3 (PR3) in human serum or plasma.

The anti-PR3 assay is an important element in the diagnosis of granulomatosis with polyangiitis (Wegener’s granulomatosis). Antineutrophil cytoplasmic antibodies (ANCA) are a group of autoantibodies directed against the cytoplasmic components of the neutrophils and monocytes. Detection of ANCA is carried out by indirect immunofluorescence (IIF), followed by antigen-specific ELISA tests such as Anti-PR3 oder Anti-PR3 hs (high sensitive) ORG 618, ORG 318).

The Anti-PR3 (hs (high sensitive) has unusually high sensitivity (96 %) and simultaneously high specificity (99 %), providing outstanding diagnostic power in ANCA diagnosis. In addition, results from this test correlate excellently with those of indirect immunofluorescence tests.

Specifications

Product Number ORG 218
Tests24 Alegria® strips
Calibrationinternal
Calculationquantitative
Range0 - 100 U/ml
Cut-off5 U/ml
Coating proteinase 3
ELISA

ORG 518  

Documentation

Instruction for Use
Safety Data Sheet

Document Archive
Instruction for Use Revision 4. Earlier versions and additional languages can be found in the document archive.
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