Anti-PR3 hs

Anti-PR3 hs is an ELISA-based, automated, in-vitro test system for the quantitative determination of IgG antibodies against proteinase 3 (PR3) in human serum or plasma.

The Anti-PR3 assay is an important element in the diagnosis of granulomatosis with polyangiitis (Wegener’s granulomatosis). Autoantibodies directed against PR3 play a critical role in the diagnosis of this life-threatening disease. A combination of indirect immunofluorescence (IIF) and an antigen-specific ELISA is currently recommended for the detection of these autoantibodies.

Based on a special coating technology, Anti-PR3 hs (high sensitive) (ORG 618, ORG 318) now represents an innovative ELISA whose extraordinarily high sensitivity of 96 % and specificity of 99 % provide outstanding diagnostic significance in ANCA serology. In addition, the results of Anti-PR3 hs (high sensitive) correlate well with those of IIF.

Specifications

Product Number ORG 318
Tests24 Alegria® strips
Calibrationinternal
Calculationquantitative
Range0 - 200 U/ml
Cut-off10 U/ml
Coating proteinase 3 (PR3)
Alegria

ORG 389  

ELISA

ORG 530   ORG 618   ORG 689  

BLOT

ORG 789  

Documentation

Instruction for Use
Safety Data Sheet

Document Archive
Instruction for Use Revision 4. Earlier versions and additional languages can be found in the document archive.