Anti-LC1

Anti-LC1 is an ELISA-based, automated, in-vitro test system for the quantitative determination of IgG antibodies against liver cytosolic protein type 1 (LC1) in human serum or plasma. It is used to support the differential diagnosis of liver diseases, particularly in cases of suspected type 2 autoimmune hepatitis.

The detection of autoantibodies plays a central role in the diagnosis of inflammatory liver diseases namely autoimmune hepatitis (AIH), primary biliary cirrhosis and sclerosing cholangitis in adults and children. Anti-smooth muscle antibodies (ASMA), anti-nuclear antibodies (ANA), and antibodies against the soluble liver antigen (anti-SLA) define AIH type 1. Liver-kidney microsome antibodies (anti-LKM-1) and liver cytosolic protein type 1 antibodies (anti-LC1) may be present in AIH type 2. Anti-LC1 may be the single antibody in up to one third of the patients with AIH-2, and AIH-2 patients with anti-LC1 antibodies have histologically more severe disease compared to those without anti-LC1 antibodies. Anti-LC1 was originally described in association with anti-LKM-1, or in isolation in patients with AIH-2. Anti-LC1 antibodies have also been found in 14 % anti-LKM-1 antibody positive patients suffering from chronic hepatitis C virus infection.

Specifications

Product Number ORG 258
Tests24 Alegria® Test Strips
Calibrationinternal
Calculationquantitative
Range0 - 100 U/ml
Cut-off10 U/ml
Coating LC1 (liver cytosolic protein type 1)
BLOT

ORG 722  

Documentation

Instruction for Use
Safety Data Sheet
Product Information

Document Archive
Instruction for Use Revision 2. Earlier versions and additional languages can be found in the document archive.

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