Anti-Sm

Anti-Sm is an ELISA-based, automated, in-vitro test system for the quantitative determination of IgG antibodies against Sm proteins in human serum or plasma.
Sm proteins are extractable nuclear antigens (ENA). Detection of autoantibodies against these proteins is one of the ACR criteria for the diagnosis of systemic lupus erythematosus (SLE).

The detection of autoantibodies against Sm proteins is one of the ACR criteria for the diagnosis of systemic lupus erythematosus (SLE). Because of the very high specificity (99 %) of this marker for SLE, the reliable detection of Sm autoantibodies suffices as a diagnostic criterion for the disease when fewer than three clinical ACR criteria have been met. However, a negative result does not rule out SLE. The detection of Sm antibodies serves as a prognostic marker for SLE. Obviously, there is a relationship between the appearance of Sm antibodies and severe organ manifestations of the disease.

Specifications

Product Number ORG 210
Tests24 Alegria® strips
Calculationquantitative
Range0 - 200 U/ml
Cut-off 25 U/ml
Coating Sm ribonucleoproteins
Alegria

ORG 206   ORG 238  

ELISA

ORG 506   ORG 510   ORG 514   ORG 544  

BLOT

ORG 710   ORG 711  

Documentation

Instruction for Use
Safety Data Sheet

Document Archive
Instruction for Use Revision 4. Earlier versions and additional languages can be found in the document archive.

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