Anti-Measles Virus IgG Liquor

Anti-Measles Virus IgG is an ELISA-based, automated, in-vitro test system for the comparative quantitative determination of IgG antibodies against measles virus in human serum or plasma. This test is used to detect IgG antibody synthesis in the central nervous system.

Measles infection causes encephalitis in about 1 in 1000 children. The most threatening complication of measles infection is subacute sclerosing panencephalitis (SSPE), which occurs in approximately one in 10000 children and is always fatal. SSPE is a late complication that starts usually four to ten years after a measles infection. An increased titer of specific antibodies to measles virus is found in the CSF of the affected children.
In chronic diseases with CNS involvement, e.g. multiple sclerosis (MS) or Lupus with neurological manifestations, an elevated antibody index of anti-measles virus, anti-rubella virus and / or anti-varicella zoster virus can be detected in the CSF. This MRZ reaction is the most sensitive biochemical method for the detection of the pathological immune process in the CNS when the first clinical symptoms of MS appear. In about 90% of MS patients, an increased antibody index against the MRZ combination can be detected.

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