Anti-Centromere B
Anti-Centromere B is an ELISA test system for the quantitative determination of IgG antibodies against centromere B in human serum or plasma.
The detection of autoantibodies against centromere protein B is of great diagnostic and prognostic importance in cases of progressive systemic scleroderma (PSS).
Centromere protein B is a DNA-associated protein. Together with other proteins, it forms the kinetochores of the chromosomes. Centromere B is the target antigen in over 95 % of patients with scleroderma or Raynaud’s phenomenon. Because autoantibodies against centromere proteins sometimes appear years before the disease appears, detection of anti-centromere B can be a significant indicator for the onset of scleroderma.
CREST syndrome, a limited and localized form of scleroderma with a more favourable prognosis can be serologically detected at an early stage with use of the ORGENTEC Anti-Centromere B test.
Specifications
Product Number |
ORG 633 |
Tests | 12 x 8 tests |
Calibration | internal |
Calculation | quantitative |
Range | 0 - 300 U/ml |
Cut-off | 10 U/ml |
Coating |
centromere B |
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Instruction for Use Revision 4. Earlier versions and additional languages can be found in the document archive.
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