Anti-Scl-70
Anti-Scl-70 is an ELISA-based, automated, in-vitro test system for the quantitative determination of IgG antibodies against Scl-70 (DNA topoisomerase I) in human serum or plasma.
With a specificity near 100 %, these antibodies are an accepted and highly specific marker for progressive systemic scleroderma; autoantibodies against topoisomerase I are extremely rare in both healthy individuals and those with non-autoimmune diseases.
In addition to the serological diagnosis of systemic scleroderma, ORGENTEC’s Anti-Sci-70 test is also useful in the differential diagnosis of Raynaud’s phenomenon. Autoantibodies against topoisomerase I are also a prognostic marker for the further development of systemic sclerosis.
Specifications
| Product Number |
ORG 212 |
| Tests | 24 Alegria® strips |
| Calculation | quantitative |
| Range | 0 - 200 U/ml |
| Cut-off | 25 U/ml |
| Coating |
Scl-70 protein (DNA topoisomerase I) |
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Instruction for Use Revision 4. Earlier versions and additional languages can be found in the document archive.
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