Anti-dsDNA

Anti-dsDNA IgG is an ELISA test for the quantitative determination of IgG antibodies against double-stranded DNA in human serum or plasma.

This assay is used for initial diagnosis in cases of systemic lupus erythematosus and for differential diagnosis of systemic autoimmune diseases for which high titres of antibodies against antinuclear antibodies (ANA) are found. Autoantibodies against DNA and histones bind to single-stranded (ssDNA) and double-stranded (dsDNA). Antibodies against dsDNA are predominantly detected during the active stages of the disease and serve as activity markers for SLE. They are a prognostic indicator of severe, multisystemic disease progression.

Specifications