ENAscreen is an ELISA test system for the qualitative determination IgG antibodies against extractable nuclear antigens (ENA) in human serum or plasma. It is used in cases of suspected connective tissue disease (CTD).

Besides DNA and histones, autoantibodies may also target other nuclear antigens. These nuclear antigens were named extractable nuclear antigens (ENA), as originally they were extracted from the nuclei with saline solution. Autoantibodies to Smith antigen (Sm) which is also considered to be highly specific for SLE were the first anti-ENA detected. Thereafter, further subtypes of ENA i.e. ribonucleoproteins (RNP), the Sjoegren antigens SS-A and SS-B, Scl-70, and Jo-1 were identified. Each individual well of the ENAscreen test is coated with a mixture of six highly purified antigens. For further differentiation, a positive result with this ELISA may then be followed up with ENAcombi or the ORGENTEC test kits for quantitative determination of the individual ENA specificities.


Product Number ORG 506
Tests12 x 8 tests
CalibrationCDC sera
Cut-offIndex > 1.0
Coating histidyl-tRNA synthetase (Jo-1), RNP/Sm complex, Scl-70 protein (DNA topoisomerase I), Sm ribonucleoproteins, SS-A 52 (Ro 52), SS-A 60 (Ro 60), SS-B (La)

ORG 200   ORG 206   ORG 213   ORG 238   ORG 211   ORG 212   ORG 210   ORG 208   ORG 252   ORG 260   ORG 209  


ORG 513   ORG 514   ORG 538   ORG 539   ORG 600   ORG 511   ORG 512   ORG 510   ORG 508   ORG 652   ORG 660   ORG 509  


Instruction for Use
Safety Data Sheet

Document Archive
Instruction for Use Revision 3. Earlier versions and additional languages can be found in the document archive.

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