Anti-Prothrombin IgG/IgM

Anti-Prothrombin IgG/IgM is an ELISA test for the quantitative determination of IgG and IgM antibodies against prothrombin in human serum or plasma.

Antiphospholipid syndrome (APS, Hughes syndrome) is a systemic autoimmune disease that may cause thromboses, recurring miscarriage, and intrauterine foetal death. In addition to these clinical symptoms, specific autoantibodies can be detected in blood samples from APS patients. These antibodies bind to phospholipids like cardiolipin or phospholipid-binding proteins like beta-2-glycoprotein. The detection of prothrombin autoantibodies supports the diagnosis of antiphospholipid syndrome (APS) especially when cardiolipin antibodies are not detected. In high-risk groups for secondary APS such as SLE and scleroderma patients, these tests make it possible to assess the risk of thrombosis.

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