Anti-Hepatitis E Virus

The hepatitis E virus is a small, non-enveloped virus with a single-stranded RNA genome. Along with hepatitis A, hepatitis E is one of the primary causes of acute hepatitis. The virus is transmitted by a faecal-oral route, through contaminated drinking water countries and through undercooked meat. Laboratory diagnosis of HEV infection depends on the detection of impaired liver function (elevated serum level of liver enzymes), as well as the direct or indirect detection of the virus. Because cases of hepatitis E cannot be distinguished clinically from other types of acute viral hepatitis, hepatitis E should always be considered in the differential diagnosis of acute hepatitis. During the viremic phase, HEV RNA can be detected in both the blood and stool by means of RT-PCR. However, the serological detection of virus-specific antibodies is more meaningful. The IgM response is generally positive four weeks after infection when clinical symptoms begin. The IgG antibodies then increase and reach their maximum about four weeks later. Anti HEV antibodies are predominantly directed against epitopes of ORF2. This test uses recombinant ORF2 from genotypes 1 and 3 as antigen. Due to cross reactions, antibodies against genotypes 2 and 4 are also detected.

Anti-Hepatitis E Virus IgM Abs.

The Alegria^® Anti-Hepatitis E Virus IgM Abs. is an ELISA-based test system for the quantitative measurement of IgM class antibodies against Hepatitis E Virus in human serum or plasma samples.

Specifications

Anti-Hepatitis E Virus IgG

The Alegria^® Anti-Hepatitis E Virus IgG is an ELISA-based test system for the quantitative measurement of IgG class antibodies against Hepatitis E Virus in human serum or plasma samples.

Specifications