Anti-PR3 (cANCA)
Anti-PR3 is an ELISA test for the quantitative determination of IgG antibodies against proteinase 3 (PR3) in human serum or plasma.
The anti-PR3 assay is an important element in the diagnosis of granulomatosis with polyangiitis (Wegener’s granulomatosis).
Antineutrophil cytoplasmic antibodies (ANCA) are a group of autoantibodies directed against the cytoplasmic components of the neutrophils and monocytes. Detection of ANCA is carried out by indirect immunofluorescence (IIF), followed by antigen-specific ELISA tests such as Anti-PR3 oder Anti-PR3 hs (high sensitive) ORG 618, ORG 318).
The Anti-PR3
(hs (high sensitive) has unusually high sensitivity (96 %) and simultaneously high specificity (99 %), providing outstanding diagnostic power in ANCA diagnosis. In addition, results from this test correlate excellently with those of indirect immunofluorescence tests.
Specifications
| Product Number |
ORG 518 |
| Tests | 12 x 8 tests |
| Calibration | internal |
| Calculation | quantitative |
| Range | 0 - 100 U/ml |
| Cut-off | 5 U/ml |
| Coating |
proteinase 3 |
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Instruction for Use Revision 3. Earlier versions and additional languages can be found in the document archive.
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