Anti-Centromere B

Anti-Centromere B is an ELISA-based, automated, in-vitro test system for the quantitative determination of IgG antibodies against centromere B in human serum or plasma.

The detection of autoantibodies against centromere protein B is of great diagnostic and prognostic importance in cases of progressive systemic scleroderma (PSS). Centromere protein B is a DNA-associated protein. Together with other proteins, it forms the kinetochores of the chromosomes. Centromere B is the target antigen in over 95 % of patients with scleroderma or Raynaud’s phenomenon. Because autoantibodies against centromere proteins sometimes appear years before the disease appears, detection of anti-centromere B can be a significant indicator for the onset of scleroderma. CREST syndrome, a limited and localized form of scleroderma with a more favourable prognosis can be serologically detected at an early stage with use of the ORGENTEC Anti-Centromere B test.

Specifications

Product Number ORG 233
Tests24 Alegria® strips
CalibrationCDC sera
Calculationquantitative
Range0 - 300 U/ml
Cut-off10 U/ml
Coating centromere B
Alegria

ORG 200   ORG 238  

ELISA

ORG 538   ORG 539   ORG 600   ORG 633  

BLOT

ORG 710   ORG 711  

Documentation

Instruction for Use
Safety Data Sheet

Document Archive
Instruction for Use Revision 4. Earlier versions and additional languages can be found in the document archive.
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