Anti-RNP-70 is an ELISA-based, automated, in-vitro test system for the quantitative determination of IgG antibodies against RNP-70 in human serum or plasma.

RNP-70, the 70 kDa protein of the U1-snRNP complex, is one of the extractable nuclear antigens (ENA). It is useful for the diagnosis of mixed connective tissue disease (MCTD, Sharp syndrome) and related autoimmune diseases. The diagnostic sensitivity of this marker for MCTD is 100 %; absence of RNP-70 autoantibodies rules out MCTD. Antibodies against RNP-70 are found in up to 32 % of cases of systemic lupus erythematosus (SLE) and up to 10 % of systemic scleroderma cases.


Product Number ORG 232
Tests24 Alegria® strips
CalibrationCDC sera
Range0 - 200 U/ml
Cut-off25 U/ml
Coating RNP-70

ORG 200   ORG 238  


ORG 538   ORG 539   ORG 546   ORG 600   ORG 632  


Instruction for Use
Safety Data Sheet

Document Archive
Instruction for Use Revision 5. Earlier versions and additional languages can be found in the document archive.
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