Anti-MCV®

Anti-MCV® is an ELISA test for the quantitative determination of IgG antibodies against mutated citrullinated vimentin (MCV) in human serum or plasma. It is a powerful serological test for rheumatoid arthritis, especially in early disease.

Anti-MCV® detects the disease at a very early stage, even in patients who test negative for rheumatoid factor and to some degree even before the appearance of specific clinical symptoms. Autoantibodies against mutated citrullinated vimentin are highly specific and extremely sensitive markers for rheumatoid arthritis (97 % specificity, >82 % sensitivity). Anti-MCV autoantibodies are an indicator of advancing damage to the joints and aggressive progression of the disease. In contrast to the detection of antibodies against synthetic cyclic citrullinated peptides, changes in the concentration of anti-MCV correspond to changes in the clinical parameters. As well as allowing for an unambiguous diagnosis, the Anti-MCV ELISA thus also makes it possible to monitor the progress of treatment.

Specifications

Product Number ORG 548
Tests12 x 8 tests
Calibrationinternal
Calculationquantitative
Range0 - 1000 U/ml
Cut-off20 U/ml
Coating MCV (mutated citrullinated vimentin)
Alegria

ORG 248  

Documentation

Instruction for Use
Safety Data Sheet

Document Archive
Instruction for Use Revision 5. Earlier versions and additional languages can be found in the document archive.

We use cookies on our website. Some of them are essential for the operation of the site, while others help us to improve this site and the user experience (tracking cookies). You can decide for yourself whether you want to allow cookies or not. Please note that if you reject them, you may not be able to use all the functionalities of the site.